Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (10): 794-797.doi: 10.3760/cma.j.issn.1673-422X.2017.10.018

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Role of insulinlike growth factors family in endometrial cancer

Gao Wuyuan, Wang Lihua   

  1. Department of Gynecologic Oncology, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-10-08 Published:2017-11-08
  • Contact: Wang Lihua
  • Supported by:
    National Natural Science Foundation of China (81572547)

Abstract: The expression and activity of insulinlike growth factors (IGFs) are increased in endometrial cancer (EC). IGFs not only mediate the positive impact of estrogen on EC, but also increase the risk for development of EC in patients with metabolic disorder. In addition, IGFs play a key role in the invasion, metastasis and drug resistance of EC. Thus, drugs that target IGFs may be the novel treatment of EC.

Key words: Endometrial neoplasms, Insulinlike growth factors